Using multiplexed assays of oncogenic drivers in lung cancers to select targeted drugs.
Identifieur interne : 000934 ( Main/Exploration ); précédent : 000933; suivant : 000935Using multiplexed assays of oncogenic drivers in lung cancers to select targeted drugs.
Auteurs : Mark G. Kris [États-Unis] ; Bruce E. Johnson [États-Unis] ; Lynne D. Berry [États-Unis] ; David J. Kwiatkowski [États-Unis] ; A John Iafrate [États-Unis] ; Ignacio I. Wistuba [États-Unis] ; Marileila Varella-Garcia ; Wilbur A. Franklin ; Samuel L. Aronson [États-Unis] ; Pei-Fang Su [États-Unis] ; Yu Shyr [États-Unis] ; D Ross Camidge ; Lecia V. Sequist [États-Unis] ; Bonnie S. Glisson [États-Unis] ; Fadlo R. Khuri [Géorgie (pays)] ; Edward B. Garon [États-Unis] ; William Pao [États-Unis] ; Charles Rudin [États-Unis] ; Joan Schiller [États-Unis] ; Eric B. Haura [États-Unis] ; Mark Socinski [États-Unis] ; Keisuke Shirai ; Heidi Chen [États-Unis] ; Giuseppe Giaccone [États-Unis] ; Marc Ladanyi [États-Unis] ; Kelly Kugler ; John D. Minna [États-Unis] ; Paul A. BunnSource :
- JAMA [ 1538-3598 ] ; 2014.
Descripteurs français
- KwdFr :
- Adulte d'âge moyen, Adénocarcinome (génétique), Adénocarcinome (traitement médicamenteux), Analyse de survie, Analyse de séquence d'ADN (), Femelle, Génotype, Humains, Mâle, Proto-oncogènes, Réaction de polymérisation en chaine multiplex, Spectrométrie de masse MALDI, Sujet âgé, Thérapie moléculaire ciblée, Tumeurs du poumon (génétique), Tumeurs du poumon (traitement médicamenteux).
- MESH :
- génétique : Adénocarcinome, Tumeurs du poumon.
- traitement médicamenteux : Adénocarcinome, Tumeurs du poumon.
- Adulte d'âge moyen, Analyse de survie, Analyse de séquence d'ADN, Femelle, Génotype, Humains, Mâle, Proto-oncogènes, Réaction de polymérisation en chaine multiplex, Spectrométrie de masse MALDI, Sujet âgé, Thérapie moléculaire ciblée.
English descriptors
- KwdEn :
- Adenocarcinoma (drug therapy), Adenocarcinoma (genetics), Aged, Female, Genotype, Humans, Lung Neoplasms (drug therapy), Lung Neoplasms (genetics), Male, Middle Aged, Molecular Targeted Therapy, Multiplex Polymerase Chain Reaction, Proto-Oncogenes, Sequence Analysis, DNA (methods), Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Survival Analysis.
- MESH :
- drug therapy : Adenocarcinoma, Lung Neoplasms.
- genetics : Adenocarcinoma, Lung Neoplasms.
- methods : Sequence Analysis, DNA.
- Aged, Female, Genotype, Humans, Male, Middle Aged, Molecular Targeted Therapy, Multiplex Polymerase Chain Reaction, Proto-Oncogenes, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Survival Analysis.
Abstract
Targeting oncogenic drivers (genomic alterations critical to cancer development and maintenance) has transformed the care of patients with lung adenocarcinomas. The Lung Cancer Mutation Consortium was formed to perform multiplexed assays testing adenocarcinomas of the lung for drivers in 10 genes to enable clinicians to select targeted treatments and enroll patients into clinical trials.
DOI: 10.1001/jama.2014.3741
PubMed: 24846037
Affiliations:
- Géorgie (pays), États-Unis
- Californie, District de Columbia, Floride, Maryland, Massachusetts, Pennsylvanie, Tennessee, Texas, État de New York
- Boston, Dallas, Houston, Los Angeles
Links toward previous steps (curation, corpus...)
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- to stream PubMed, to step Checkpoint: 002F06
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- to stream Ncbi, to step Curation: 002129
- to stream Ncbi, to step Checkpoint: 002129
- to stream Main, to step Merge: 000939
- to stream Main, to step Curation: 000934
Le document en format XML
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Aronson</name><affiliation wicri:level="2"><nlm:affiliation>The Partners HealthCare Center for Personalized Genetic Medicine, Boston, Massachusetts.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>The Partners HealthCare Center for Personalized Genetic Medicine, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Su, Pei Fang" sort="Su, Pei Fang" uniqKey="Su P" first="Pei-Fang" last="Su">Pei-Fang Su</name><affiliation wicri:level="2"><nlm:affiliation>Vanderbilt-Ingram Cancer Center, Nashville, Tennessee.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Vanderbilt-Ingram Cancer Center, Nashville</wicri:cityArea></affiliation></author><author><name sortKey="Shyr, Yu" sort="Shyr, Yu" uniqKey="Shyr Y" first="Yu" last="Shyr">Yu Shyr</name><affiliation wicri:level="2"><nlm:affiliation>Vanderbilt-Ingram Cancer Center, Nashville, Tennessee.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Vanderbilt-Ingram Cancer Center, Nashville</wicri:cityArea></affiliation></author><author><name sortKey="Camidge, D Ross" sort="Camidge, D Ross" uniqKey="Camidge D" first="D Ross" last="Camidge">D Ross Camidge</name><affiliation><nlm:affiliation>University of Colorado Cancer Center Denver, Aurora.</nlm:affiliation><wicri:noCountry code="subField">Aurora</wicri:noCountry></affiliation></author><author><name sortKey="Sequist, Lecia V" sort="Sequist, Lecia V" uniqKey="Sequist L" first="Lecia V" last="Sequist">Lecia V. 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Haura</name><affiliation wicri:level="2"><nlm:affiliation>H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>H. Lee Moffitt Cancer Center & Research Institute, Tampa</wicri:cityArea></affiliation></author><author><name sortKey="Socinski, Mark" sort="Socinski, Mark" uniqKey="Socinski M" first="Mark" last="Socinski">Mark Socinski</name><affiliation wicri:level="2"><nlm:affiliation>University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>University of Pittsburgh Cancer Institute, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Shirai, Keisuke" sort="Shirai, Keisuke" uniqKey="Shirai K" first="Keisuke" last="Shirai">Keisuke Shirai</name><affiliation><nlm:affiliation>Medical University of South Carolina, Charleston.</nlm:affiliation><wicri:noCountry code="subField">Charleston</wicri:noCountry></affiliation></author><author><name sortKey="Chen, Heidi" sort="Chen, Heidi" uniqKey="Chen H" first="Heidi" last="Chen">Heidi Chen</name><affiliation wicri:level="2"><nlm:affiliation>Vanderbilt-Ingram Cancer Center, Nashville, Tennessee.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Vanderbilt-Ingram Cancer Center, Nashville</wicri:cityArea></affiliation></author><author><name sortKey="Giaccone, Giuseppe" sort="Giaccone, Giuseppe" uniqKey="Giaccone G" first="Giuseppe" last="Giaccone">Giuseppe Giaccone</name><affiliation wicri:level="2"><nlm:affiliation>National Cancer Institute, Bethesda, Maryland17Georgetown University School of Medicine, Washington, DC.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">District de Columbia</region></placeName><wicri:cityArea>National Cancer Institute, Bethesda, Maryland17Georgetown University School of Medicine, Washington</wicri:cityArea></affiliation></author><author><name sortKey="Ladanyi, Marc" sort="Ladanyi, Marc" uniqKey="Ladanyi M" first="Marc" last="Ladanyi">Marc Ladanyi</name><affiliation wicri:level="2"><nlm:affiliation>Memorial Sloan Kettering Cancer Center, New York, New York.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Memorial Sloan Kettering Cancer Center, New York</wicri:cityArea></affiliation></author><author><name sortKey="Kugler, Kelly" sort="Kugler, Kelly" uniqKey="Kugler K" first="Kelly" last="Kugler">Kelly Kugler</name><affiliation><nlm:affiliation>University of Colorado Cancer Center Denver, Aurora.</nlm:affiliation><wicri:noCountry code="subField">Aurora</wicri:noCountry></affiliation></author><author><name sortKey="Minna, John D" sort="Minna, John D" uniqKey="Minna J" first="John D" last="Minna">John D. Minna</name><affiliation wicri:level="3"><nlm:affiliation>University of Texas Southwestern, Medical Center, Dallas.</nlm:affiliation><country>États-Unis</country><placeName><settlement type="city">Dallas</settlement><region type="state">Texas</region></placeName><wicri:orgArea>University of Texas Southwestern, Medical Center</wicri:orgArea></affiliation></author><author><name sortKey="Bunn, Paul A" sort="Bunn, Paul A" uniqKey="Bunn P" first="Paul A" last="Bunn">Paul A. Bunn</name><affiliation><nlm:affiliation>University of Colorado Cancer Center Denver, Aurora.</nlm:affiliation><wicri:noCountry code="subField">Aurora</wicri:noCountry></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:24846037</idno><idno type="pmid">24846037</idno><idno type="doi">10.1001/jama.2014.3741</idno><idno type="wicri:Area/PubMed/Corpus">002F26</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002F26</idno><idno type="wicri:Area/PubMed/Curation">002F06</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002F06</idno><idno type="wicri:Area/PubMed/Checkpoint">002F06</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002F06</idno><idno type="wicri:Area/Ncbi/Merge">002129</idno><idno type="wicri:Area/Ncbi/Curation">002129</idno><idno type="wicri:Area/Ncbi/Checkpoint">002129</idno><idno type="wicri:Area/Main/Merge">000939</idno><idno type="wicri:Area/Main/Curation">000934</idno><idno type="wicri:Area/Main/Exploration">000934</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Using multiplexed assays of oncogenic drivers in lung cancers to select targeted drugs.</title><author><name sortKey="Kris, Mark G" sort="Kris, Mark G" uniqKey="Kris M" first="Mark G" last="Kris">Mark G. Kris</name><affiliation wicri:level="2"><nlm:affiliation>Memorial Sloan Kettering Cancer Center, New York, New York.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Memorial Sloan Kettering Cancer Center, New York</wicri:cityArea></affiliation></author><author><name sortKey="Johnson, Bruce E" sort="Johnson, Bruce E" uniqKey="Johnson B" first="Bruce E" last="Johnson">Bruce E. Johnson</name><affiliation wicri:level="2"><nlm:affiliation>Dana-Farber Cancer Institute, Boston, Massachusetts.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Dana-Farber Cancer Institute, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Berry, Lynne D" sort="Berry, Lynne D" uniqKey="Berry L" first="Lynne D" last="Berry">Lynne D. Berry</name><affiliation wicri:level="2"><nlm:affiliation>Vanderbilt-Ingram Cancer Center, Nashville, Tennessee.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Vanderbilt-Ingram Cancer Center, Nashville</wicri:cityArea></affiliation></author><author><name sortKey="Kwiatkowski, David J" sort="Kwiatkowski, David J" uniqKey="Kwiatkowski D" first="David J" last="Kwiatkowski">David J. Kwiatkowski</name><affiliation wicri:level="2"><nlm:affiliation>Brigham and Women's Hospital, Boston, Massachusetts.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Brigham and Women's Hospital, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Iafrate, A John" sort="Iafrate, A John" uniqKey="Iafrate A" first="A John" last="Iafrate">A John Iafrate</name><affiliation wicri:level="3"><nlm:affiliation>Massachusetts General Hospital, Boston.</nlm:affiliation><country>États-Unis</country><placeName><settlement type="city">Boston</settlement><region type="state">Massachusetts</region></placeName><wicri:orgArea>Massachusetts General Hospital</wicri:orgArea></affiliation></author><author><name sortKey="Wistuba, Ignacio I" sort="Wistuba, Ignacio I" uniqKey="Wistuba I" first="Ignacio I" last="Wistuba">Ignacio I. Wistuba</name><affiliation wicri:level="3"><nlm:affiliation>The University of Texas MD Anderson Cancer Center, Houston.</nlm:affiliation><country>États-Unis</country><placeName><settlement type="city">Houston</settlement><region type="state">Texas</region></placeName><wicri:orgArea>The University of Texas MD Anderson Cancer Center</wicri:orgArea></affiliation></author><author><name sortKey="Varella Garcia, Marileila" sort="Varella Garcia, Marileila" uniqKey="Varella Garcia M" first="Marileila" last="Varella-Garcia">Marileila Varella-Garcia</name><affiliation><nlm:affiliation>University of Colorado Cancer Center Denver, Aurora.</nlm:affiliation><wicri:noCountry code="subField">Aurora</wicri:noCountry></affiliation></author><author><name sortKey="Franklin, Wilbur A" sort="Franklin, Wilbur A" uniqKey="Franklin W" first="Wilbur A" last="Franklin">Wilbur A. Franklin</name><affiliation><nlm:affiliation>University of Colorado Cancer Center Denver, Aurora.</nlm:affiliation><wicri:noCountry code="subField">Aurora</wicri:noCountry></affiliation></author><author><name sortKey="Aronson, Samuel L" sort="Aronson, Samuel L" uniqKey="Aronson S" first="Samuel L" last="Aronson">Samuel L. Aronson</name><affiliation wicri:level="2"><nlm:affiliation>The Partners HealthCare Center for Personalized Genetic Medicine, Boston, Massachusetts.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>The Partners HealthCare Center for Personalized Genetic Medicine, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Su, Pei Fang" sort="Su, Pei Fang" uniqKey="Su P" first="Pei-Fang" last="Su">Pei-Fang Su</name><affiliation wicri:level="2"><nlm:affiliation>Vanderbilt-Ingram Cancer Center, Nashville, Tennessee.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Vanderbilt-Ingram Cancer Center, Nashville</wicri:cityArea></affiliation></author><author><name sortKey="Shyr, Yu" sort="Shyr, Yu" uniqKey="Shyr Y" first="Yu" last="Shyr">Yu Shyr</name><affiliation wicri:level="2"><nlm:affiliation>Vanderbilt-Ingram Cancer Center, Nashville, Tennessee.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Vanderbilt-Ingram Cancer Center, Nashville</wicri:cityArea></affiliation></author><author><name sortKey="Camidge, D Ross" sort="Camidge, D Ross" uniqKey="Camidge D" first="D Ross" last="Camidge">D Ross Camidge</name><affiliation><nlm:affiliation>University of Colorado Cancer Center Denver, Aurora.</nlm:affiliation><wicri:noCountry code="subField">Aurora</wicri:noCountry></affiliation></author><author><name sortKey="Sequist, Lecia V" sort="Sequist, Lecia V" uniqKey="Sequist L" first="Lecia V" last="Sequist">Lecia V. Sequist</name><affiliation wicri:level="3"><nlm:affiliation>Massachusetts General Hospital, Boston.</nlm:affiliation><country>États-Unis</country><placeName><settlement type="city">Boston</settlement><region type="state">Massachusetts</region></placeName><wicri:orgArea>Massachusetts General Hospital</wicri:orgArea></affiliation></author><author><name sortKey="Glisson, Bonnie S" sort="Glisson, Bonnie S" uniqKey="Glisson B" first="Bonnie S" last="Glisson">Bonnie S. Glisson</name><affiliation wicri:level="3"><nlm:affiliation>The University of Texas MD Anderson Cancer Center, Houston.</nlm:affiliation><country>États-Unis</country><placeName><settlement type="city">Houston</settlement><region type="state">Texas</region></placeName><wicri:orgArea>The University of Texas MD Anderson Cancer Center</wicri:orgArea></affiliation></author><author><name sortKey="Khuri, Fadlo R" sort="Khuri, Fadlo R" uniqKey="Khuri F" first="Fadlo R" last="Khuri">Fadlo R. Khuri</name><affiliation wicri:level="1"><nlm:affiliation>Winship Cancer Institute of Emory University, Atlanta, Georgia.</nlm:affiliation><country xml:lang="fr">Géorgie (pays)</country><wicri:regionArea>Winship Cancer Institute of Emory University, Atlanta</wicri:regionArea><wicri:noRegion>Atlanta</wicri:noRegion></affiliation></author><author><name sortKey="Garon, Edward B" sort="Garon, Edward B" uniqKey="Garon E" first="Edward B" last="Garon">Edward B. Garon</name><affiliation wicri:level="3"><nlm:affiliation>David Geffen School of Medicine, University of California, Los Angeles.</nlm:affiliation><country>États-Unis</country><placeName><settlement type="city">Los Angeles</settlement><region type="state">Californie</region></placeName><wicri:orgArea>David Geffen School of Medicine, University of California</wicri:orgArea></affiliation></author><author><name sortKey="Pao, William" sort="Pao, William" uniqKey="Pao W" first="William" last="Pao">William Pao</name><affiliation wicri:level="2"><nlm:affiliation>Vanderbilt-Ingram Cancer Center, Nashville, Tennessee.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Vanderbilt-Ingram Cancer Center, Nashville</wicri:cityArea></affiliation></author><author><name sortKey="Rudin, Charles" sort="Rudin, Charles" uniqKey="Rudin C" first="Charles" last="Rudin">Charles Rudin</name><affiliation wicri:level="2"><nlm:affiliation>The John Hopkins University, The Sidney Kimmel Comprehensive Cancer Center, Baltimore, Maryland.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>The John Hopkins University, The Sidney Kimmel Comprehensive Cancer Center, Baltimore</wicri:cityArea></affiliation></author><author><name sortKey="Schiller, Joan" sort="Schiller, Joan" uniqKey="Schiller J" first="Joan" last="Schiller">Joan Schiller</name><affiliation wicri:level="3"><nlm:affiliation>University of Texas Southwestern, Medical Center, Dallas.</nlm:affiliation><country>États-Unis</country><placeName><settlement type="city">Dallas</settlement><region type="state">Texas</region></placeName><wicri:orgArea>University of Texas Southwestern, Medical Center</wicri:orgArea></affiliation></author><author><name sortKey="Haura, Eric B" sort="Haura, Eric B" uniqKey="Haura E" first="Eric B" last="Haura">Eric B. Haura</name><affiliation wicri:level="2"><nlm:affiliation>H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>H. Lee Moffitt Cancer Center & Research Institute, Tampa</wicri:cityArea></affiliation></author><author><name sortKey="Socinski, Mark" sort="Socinski, Mark" uniqKey="Socinski M" first="Mark" last="Socinski">Mark Socinski</name><affiliation wicri:level="2"><nlm:affiliation>University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>University of Pittsburgh Cancer Institute, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Shirai, Keisuke" sort="Shirai, Keisuke" uniqKey="Shirai K" first="Keisuke" last="Shirai">Keisuke Shirai</name><affiliation><nlm:affiliation>Medical University of South Carolina, Charleston.</nlm:affiliation><wicri:noCountry code="subField">Charleston</wicri:noCountry></affiliation></author><author><name sortKey="Chen, Heidi" sort="Chen, Heidi" uniqKey="Chen H" first="Heidi" last="Chen">Heidi Chen</name><affiliation wicri:level="2"><nlm:affiliation>Vanderbilt-Ingram Cancer Center, Nashville, Tennessee.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Vanderbilt-Ingram Cancer Center, Nashville</wicri:cityArea></affiliation></author><author><name sortKey="Giaccone, Giuseppe" sort="Giaccone, Giuseppe" uniqKey="Giaccone G" first="Giuseppe" last="Giaccone">Giuseppe Giaccone</name><affiliation wicri:level="2"><nlm:affiliation>National Cancer Institute, Bethesda, Maryland17Georgetown University School of Medicine, Washington, DC.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">District de Columbia</region></placeName><wicri:cityArea>National Cancer Institute, Bethesda, Maryland17Georgetown University School of Medicine, Washington</wicri:cityArea></affiliation></author><author><name sortKey="Ladanyi, Marc" sort="Ladanyi, Marc" uniqKey="Ladanyi M" first="Marc" last="Ladanyi">Marc Ladanyi</name><affiliation wicri:level="2"><nlm:affiliation>Memorial Sloan Kettering Cancer Center, New York, New York.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Memorial Sloan Kettering Cancer Center, New York</wicri:cityArea></affiliation></author><author><name sortKey="Kugler, Kelly" sort="Kugler, Kelly" uniqKey="Kugler K" first="Kelly" last="Kugler">Kelly Kugler</name><affiliation><nlm:affiliation>University of Colorado Cancer Center Denver, Aurora.</nlm:affiliation><wicri:noCountry code="subField">Aurora</wicri:noCountry></affiliation></author><author><name sortKey="Minna, John D" sort="Minna, John D" uniqKey="Minna J" first="John D" last="Minna">John D. Minna</name><affiliation wicri:level="3"><nlm:affiliation>University of Texas Southwestern, Medical Center, Dallas.</nlm:affiliation><country>États-Unis</country><placeName><settlement type="city">Dallas</settlement><region type="state">Texas</region></placeName><wicri:orgArea>University of Texas Southwestern, Medical Center</wicri:orgArea></affiliation></author><author><name sortKey="Bunn, Paul A" sort="Bunn, Paul A" uniqKey="Bunn P" first="Paul A" last="Bunn">Paul A. Bunn</name><affiliation><nlm:affiliation>University of Colorado Cancer Center Denver, Aurora.</nlm:affiliation><wicri:noCountry code="subField">Aurora</wicri:noCountry></affiliation></author></analytic><series><title level="j">JAMA</title><idno type="eISSN">1538-3598</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adenocarcinoma (drug therapy)</term><term>Adenocarcinoma (genetics)</term><term>Aged</term><term>Female</term><term>Genotype</term><term>Humans</term><term>Lung Neoplasms (drug therapy)</term><term>Lung Neoplasms (genetics)</term><term>Male</term><term>Middle Aged</term><term>Molecular Targeted Therapy</term><term>Multiplex Polymerase Chain Reaction</term><term>Proto-Oncogenes</term><term>Sequence Analysis, DNA (methods)</term><term>Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization</term><term>Survival Analysis</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Adénocarcinome (génétique)</term><term>Adénocarcinome (traitement médicamenteux)</term><term>Analyse de survie</term><term>Analyse de séquence d'ADN ()</term><term>Femelle</term><term>Génotype</term><term>Humains</term><term>Mâle</term><term>Proto-oncogènes</term><term>Réaction de polymérisation en chaine multiplex</term><term>Spectrométrie de masse MALDI</term><term>Sujet âgé</term><term>Thérapie moléculaire ciblée</term><term>Tumeurs du poumon (génétique)</term><term>Tumeurs du poumon (traitement médicamenteux)</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Adenocarcinoma</term><term>Lung Neoplasms</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Adenocarcinoma</term><term>Lung Neoplasms</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Adénocarcinome</term><term>Tumeurs du poumon</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Sequence Analysis, DNA</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Adénocarcinome</term><term>Tumeurs du poumon</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Female</term><term>Genotype</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Molecular Targeted Therapy</term><term>Multiplex Polymerase Chain Reaction</term><term>Proto-Oncogenes</term><term>Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization</term><term>Survival Analysis</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Analyse de survie</term><term>Analyse de séquence d'ADN</term><term>Femelle</term><term>Génotype</term><term>Humains</term><term>Mâle</term><term>Proto-oncogènes</term><term>Réaction de polymérisation en chaine multiplex</term><term>Spectrométrie de masse MALDI</term><term>Sujet âgé</term><term>Thérapie moléculaire ciblée</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Targeting oncogenic drivers (genomic alterations critical to cancer development and maintenance) has transformed the care of patients with lung adenocarcinomas. The Lung Cancer Mutation Consortium was formed to perform multiplexed assays testing adenocarcinomas of the lung for drivers in 10 genes to enable clinicians to select targeted treatments and enroll patients into clinical trials.</div></front></TEI><affiliations><list><country><li>Géorgie (pays)</li><li>États-Unis</li></country><region><li>Californie</li><li>District de Columbia</li><li>Floride</li><li>Maryland</li><li>Massachusetts</li><li>Pennsylvanie</li><li>Tennessee</li><li>Texas</li><li>État de New York</li></region><settlement><li>Boston</li><li>Dallas</li><li>Houston</li><li>Los Angeles</li></settlement></list><tree><noCountry><name sortKey="Bunn, Paul A" sort="Bunn, Paul A" uniqKey="Bunn P" first="Paul A" last="Bunn">Paul A. Bunn</name><name sortKey="Camidge, D Ross" sort="Camidge, D Ross" uniqKey="Camidge D" first="D Ross" last="Camidge">D Ross Camidge</name><name sortKey="Franklin, Wilbur A" sort="Franklin, Wilbur A" uniqKey="Franklin W" first="Wilbur A" last="Franklin">Wilbur A. Franklin</name><name sortKey="Kugler, Kelly" sort="Kugler, Kelly" uniqKey="Kugler K" first="Kelly" last="Kugler">Kelly Kugler</name><name sortKey="Shirai, Keisuke" sort="Shirai, Keisuke" uniqKey="Shirai K" first="Keisuke" last="Shirai">Keisuke Shirai</name><name sortKey="Varella Garcia, Marileila" sort="Varella Garcia, Marileila" uniqKey="Varella Garcia M" first="Marileila" last="Varella-Garcia">Marileila Varella-Garcia</name></noCountry><country name="États-Unis"><region name="État de New York"><name sortKey="Kris, Mark G" sort="Kris, Mark G" uniqKey="Kris M" first="Mark G" last="Kris">Mark G. Kris</name></region><name sortKey="Aronson, Samuel L" sort="Aronson, Samuel L" uniqKey="Aronson S" first="Samuel L" last="Aronson">Samuel L. Aronson</name><name sortKey="Berry, Lynne D" sort="Berry, Lynne D" uniqKey="Berry L" first="Lynne D" last="Berry">Lynne D. Berry</name><name sortKey="Chen, Heidi" sort="Chen, Heidi" uniqKey="Chen H" first="Heidi" last="Chen">Heidi Chen</name><name sortKey="Garon, Edward B" sort="Garon, Edward B" uniqKey="Garon E" first="Edward B" last="Garon">Edward B. Garon</name><name sortKey="Giaccone, Giuseppe" sort="Giaccone, Giuseppe" uniqKey="Giaccone G" first="Giuseppe" last="Giaccone">Giuseppe Giaccone</name><name sortKey="Glisson, Bonnie S" sort="Glisson, Bonnie S" uniqKey="Glisson B" first="Bonnie S" last="Glisson">Bonnie S. Glisson</name><name sortKey="Haura, Eric B" sort="Haura, Eric B" uniqKey="Haura E" first="Eric B" last="Haura">Eric B. Haura</name><name sortKey="Iafrate, A John" sort="Iafrate, A John" uniqKey="Iafrate A" first="A John" last="Iafrate">A John Iafrate</name><name sortKey="Johnson, Bruce E" sort="Johnson, Bruce E" uniqKey="Johnson B" first="Bruce E" last="Johnson">Bruce E. Johnson</name><name sortKey="Kwiatkowski, David J" sort="Kwiatkowski, David J" uniqKey="Kwiatkowski D" first="David J" last="Kwiatkowski">David J. Kwiatkowski</name><name sortKey="Ladanyi, Marc" sort="Ladanyi, Marc" uniqKey="Ladanyi M" first="Marc" last="Ladanyi">Marc Ladanyi</name><name sortKey="Minna, John D" sort="Minna, John D" uniqKey="Minna J" first="John D" last="Minna">John D. Minna</name><name sortKey="Pao, William" sort="Pao, William" uniqKey="Pao W" first="William" last="Pao">William Pao</name><name sortKey="Rudin, Charles" sort="Rudin, Charles" uniqKey="Rudin C" first="Charles" last="Rudin">Charles Rudin</name><name sortKey="Schiller, Joan" sort="Schiller, Joan" uniqKey="Schiller J" first="Joan" last="Schiller">Joan Schiller</name><name sortKey="Sequist, Lecia V" sort="Sequist, Lecia V" uniqKey="Sequist L" first="Lecia V" last="Sequist">Lecia V. Sequist</name><name sortKey="Shyr, Yu" sort="Shyr, Yu" uniqKey="Shyr Y" first="Yu" last="Shyr">Yu Shyr</name><name sortKey="Socinski, Mark" sort="Socinski, Mark" uniqKey="Socinski M" first="Mark" last="Socinski">Mark Socinski</name><name sortKey="Su, Pei Fang" sort="Su, Pei Fang" uniqKey="Su P" first="Pei-Fang" last="Su">Pei-Fang Su</name><name sortKey="Wistuba, Ignacio I" sort="Wistuba, Ignacio I" uniqKey="Wistuba I" first="Ignacio I" last="Wistuba">Ignacio I. Wistuba</name></country><country name="Géorgie (pays)"><noRegion><name sortKey="Khuri, Fadlo R" sort="Khuri, Fadlo R" uniqKey="Khuri F" first="Fadlo R" last="Khuri">Fadlo R. Khuri</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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